Fig. 3. Viroporin 2B is membrane associated and leads to autophagy and changed calcium homeostasis. A: Viroporin 2B (CVB32B) inserts into cellular membranes of the host‐cell and destabilizes the membrane integrity. This leads to uncontrolled release of calcium and other ions from cell organelles. B: 3D Model of Viroporin 2B. C: Model of membrane insertion of 2B. Shown is exemplary the insertion of a 2B single protein. D: Membrane insertion of 2B under realistic conditions. 2B forms tetramers in the host‐cell membrane to maximize membrane destabilization and to enhance uncontrolled ion flow into the cytoplasm.